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(S)-Methylisothiourea sulfate

(S)-Methylisothiourea sulfate

Catalog No. BCC6791
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10mg $98.00 Ship Within 7 Days
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(S)-Methylisothiourea sulfate

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Chemical Properties of (S)-Methylisothiourea sulfate

Cas No. 867-44-7 SDF Download SDF
Synonyms SMT
Chemical Name methyl carbamimidothioate;sulfuric acid
Standard InChI InChI=1S/2C2H6N2S.H2O4S/c2*1-5-2(3)4;1-5(2,3)4/h2*1H3,(H3,3,4);(H2,1,2,3,4)
Formula C4H14N4O4S3 M.Wt 278.36
Solubility Soluble in water
Storage Store at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (S)-Methylisothiourea sulfate

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.5925 mL 17.9624 mL 35.9247 mL 71.8494 mL 89.8118 mL
5 mM 0.7185 mL 3.5925 mL 7.1849 mL 14.3699 mL 17.9624 mL
10 mM 0.3592 mL 1.7962 mL 3.5925 mL 7.1849 mL 8.9812 mL
50 mM 0.0718 mL 0.3592 mL 0.7185 mL 1.437 mL 1.7962 mL
100 mM 0.0359 mL 0.1796 mL 0.3592 mL 0.7185 mL 0.8981 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on (S)-Methylisothiourea sulfate

Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats.[Pubmed: 18573544]

The aim of this study was to evaluate the efficiency of inducible nitric oxide synthase (iNOS) specific inhibitor, S-methylisothiourea sulfate (SMT) in preventing lung injury after different pulmonary aspiration materials in rats.

S-Methylisothiourea sulfate improves renal, but not hepatic dysfunction in canine endotoxic shock model.[Pubmed: 10663292]

Excess production of nitric oxide (NO) by inducible NO synthase (iNOS) has been implicated in the pathophysiology of septic shock. This study was designed to see whether S-methylisothiourea sulfate (SMT), a selective inhibitor for iNOS, prevents cardiovascular changes and multiple organ damage in the canine endotoxic shock model.

Beneficial effects and improved survival in rodent models of septic shock with S-methylisothiourea sulfate, a potent and selective inhibitor of inducible nitric oxide synthase.[Pubmed: 7528923]

Enhanced formation of nitric oxide (NO) by both the constitutive and the inducible isoforms of NO synthase (NOS) has been implicated in the pathophysiology of a variety of diseases, including circulatory shock. Non-isoform-selective inhibition of NO formation, however, may lead to side effects by inhibiting the constitutive isoform of NOS and, thus, the various physiological actions of NO. S-Methylisothiourea sulfate (SMT) is at least 10- to 30-fold more potent as an inhibitor of inducible NOS (iNOS) in immunostimulated cultured macrophages (EC50, 6 microM) and vascular smooth muscle cells (EC50, 2 microM) than NG-methyl-L-arginine (MeArg) or any other NOS inhibitor yet known. The effect of SMT on iNOS activity can be reversed by excess L-arginine in a concentration-dependent manner. SMT (up to 1 mM) does not inhibit the activity of xanthine oxidase, diaphorase, lactate dehydrogenase, monoamine oxidase, catalase, cytochrome P450, or superoxide dismutase. SMT is equipotent with MeArg in inhibiting the endothelial, constitutive isoform of NOS in vitro and causes increases in blood pressure similar to those produced by MeArg in normal rats. SMT, however, dose-dependently reverses (0.01-3 mg/kg) the hypotension and the vascular hyporeactivity to vasoconstrictor agents caused by endotoxin [bacterial lipopolysaccharide (LPS), 10 mg/kg, i.v.] in anesthetized rats. Moreover, therapeutic administration of SMT (5 mg/kg, i.p., given 2 hr after LPS, 10 mg/kg, i.p.) attenuates the rises in plasma alanine and aspartate aminotransferases, bilirubin, and creatinine and also prevents hypocalcaemia when measured 6 hr after administration of LPS. SMT (1 mg/kg, i.p.) improves 24-hr survival of mice treated with a high dose of LPS (60 mg/kg, i.p.). Thus, SMT is a potent and selective inhibitor of iNOS and exerts beneficial effects in rodent models of septic shock. SMT, therefore, may have considerable value in the therapy of circulatory shock of various etiologies and other pathophysiological conditions associated with induction of iNOS.

[Effect of S-methylisothiourea sulfate on smooth muscle fibers].[Pubmed: 13597343]


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