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Catalog No. BCC6560
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10mg $204.00 Ship Within 7 Days
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Quality Control of (RS)-AMPA

Chemical structure


Biological Activity of (RS)-AMPA

Prototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors. Active enantiomer (S)-AMPA, inactive enantiomer (R)-AMPA and hydrobromide salt (RS)-AMPA hydrobromide also available.

(RS)-AMPA Dilution Calculator

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(RS)-AMPA Molarity Calculator



Chemical Properties of (RS)-AMPA

Cas No. 74341-63-2 SDF Download SDF
Chemical Name (RS)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Standard InChI InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
Formula C7H10N2O4 M.Wt 186.17
Solubility Soluble to 10 mM in water with gentle warming
Storage Store at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (RS)-AMPA

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 5.3714 mL 26.8572 mL 53.7143 mL 107.4287 mL 134.2859 mL
5 mM 1.0743 mL 5.3714 mL 10.7429 mL 21.4857 mL 26.8572 mL
10 mM 0.5371 mL 2.6857 mL 5.3714 mL 10.7429 mL 13.4286 mL
50 mM 0.1074 mL 0.5371 mL 1.0743 mL 2.1486 mL 2.6857 mL
100 mM 0.0537 mL 0.2686 mL 0.5371 mL 1.0743 mL 1.3429 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on (RS)-AMPA

Effects of (RS)-3,4-DCPG, a mixed AMPA antagonist/mGluR8 agonist, on aggressive behavior in mice.[Pubmed: 23034312]

Ionotropic and metabotropic (mGlu) receptors of glutamate have been suggested to be involved in the modulation of aggression. Thus, recent studies found reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient mice. Likewise, mGlu1 and 5 receptors have also been implicated in aggression regulation. (RS)-3,4-DCPG is a mixed antagonist of AMPA receptors and an agonist of mGluR8. The AMPA antagonist activity of this compound is determined by its R isomer while the S isomer is responsible for its mGluR8 agonistic properties.

Promiscuous interactions between AMPA-Rs and MAGUKs.[Pubmed: 17046684]

What controls the number of AMPA receptors at excitatory synapses? MAGUKs are known to play a critical role in this process, but which ones are involved and when has been contentious. In this issue of Neuron, Elias et al. have elucidated the roles of three MAGUKs, PSD-95, PSD-93, and SAP-102, in the targeting of AMPA receptors to synapses in hippocampal neurons.

An antagonist of glutamate metabotropic receptors, (RS)-alpha-methyl-4-carboxyphenylglycine, prevents the LTP-related increase in postsynaptic AMPA sensitivity in hippocampal slices.[Pubmed: 7694173]

(RS)-alpha-methyl-4-carboxyphenylglycine (MCPG), a compound which selectively antagonizes metabotropic glutamate receptors (mGlu-R), presents the LTP of field excitatory postsynaptic potentials (fEPSP) as well as the tetanus-induced increase in AMPA-evoked responses (fPRs) in the CA1 region of hippocampal slices. This effects of MCPG provide evidence for the involvement of mGlu-Rs in mechanisms underlying the postsynaptic maintenance of LTP, which appears to be mediated, at least partially, by an increase in sensitivity and/or number of postsynaptic AMPA receptors.


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