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(RS)-3,4-DCPG

(RS)-3,4-DCPG

Catalog No. BCC7045
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10mg $164.00 Ship Within 7 Days
50mg $692.00 Ship Within 7 Days
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Quality Control of (RS)-3,4-DCPG

Chemical structure

(RS)-3,4-DCPG

Biological Activity of (RS)-3,4-DCPG

Systemically active anticonvulsant that is 30-100-fold more potent in vivo than the separate enantiomers (S)-3,4-DCPG or (R)-3,4,-DCPG.

(RS)-3,4-DCPG Dilution Calculator

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(RS)-3,4-DCPG Molarity Calculator

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Chemical Properties of (RS)-3,4-DCPG

Cas No. 176796-64-8 SDF Download SDF
Chemical Name (RS)-3,4-Dicarboxyphenylglycine
SMILES C1=CC(=C(C=C1C(C(=O)O)N)C(=O)O)C(=O)O
Standard InChIKey IJVMOGKBEVRBPP-UHFFFAOYSA-N
Standard InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)
Formula C10H9NO6 M.Wt 239.18
Solubility Soluble to 50 mM in water
Storage Desiccate at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (RS)-3,4-DCPG

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.181 mL 20.9048 mL 41.8095 mL 83.619 mL 104.5238 mL
5 mM 0.8362 mL 4.181 mL 8.3619 mL 16.7238 mL 20.9048 mL
10 mM 0.4181 mL 2.0905 mL 4.181 mL 8.3619 mL 10.4524 mL
50 mM 0.0836 mL 0.4181 mL 0.8362 mL 1.6724 mL 2.0905 mL
100 mM 0.0418 mL 0.209 mL 0.4181 mL 0.8362 mL 1.0452 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on (RS)-3,4-DCPG

Effects of (RS)-3,4-DCPG, a mixed AMPA antagonist/mGluR8 agonist, on aggressive behavior in mice.[Pubmed: 23034312]


Ionotropic and metabotropic (mGlu) receptors of glutamate have been suggested to be involved in the modulation of aggression. Thus, recent studies found reduced aggression in AMPA-type glutamate receptor GluR-A subunit-deficient mice. Likewise, mGlu1 and 5 receptors have also been implicated in aggression regulation. (RS)-3,4-DCPG is a mixed antagonist of AMPA receptors and an agonist of mGluR8. The AMPA antagonist activity of this compound is determined by its R isomer while the S isomer is responsible for its mGluR8 agonistic properties.

Kewords:

(RS)-3,4-DCPG,176796-64-8,Neuroscience,GluR, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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