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Catalog No. BCC6581
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10mg $373.00 Ship Within 7 Days
50mg $1,568.00 Ship Within 7 Days
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Quality Control of (R)-CPP

Chemical structure


Biological Activity of (R)-CPP

Highly potent NMDA antagonist; more active isomer. Shows some selectivity for NR2A-containing receptors (Ki values are 0.041, 0.27, 0.63 and 1.99 μM for inhibition of NR2A-, NR2B-, NR2C- and NR2D-containing recombinant NMDA receptors respectively). (RS)-CPP also available.

(R)-CPP Dilution Calculator

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(R)-CPP Molarity Calculator



Chemical Properties of (R)-CPP

Cas No. 126453-07-4 SDF Download SDF
Chemical Name 3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Standard InChI InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)/t7-/m1/s1
Formula C8H17N2O5P M.Wt 252.21
Solubility Soluble to 100 mM in water
Storage Desiccate at RT
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (R)-CPP

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9649 mL 19.8247 mL 39.6495 mL 79.299 mL 99.1237 mL
5 mM 0.793 mL 3.9649 mL 7.9299 mL 15.8598 mL 19.8247 mL
10 mM 0.3965 mL 1.9825 mL 3.9649 mL 7.9299 mL 9.9124 mL
50 mM 0.0793 mL 0.3965 mL 0.793 mL 1.586 mL 1.9825 mL
100 mM 0.0396 mL 0.1982 mL 0.3965 mL 0.793 mL 0.9912 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on (R)-CPP

Stereoselective enhancement by (R)-HA-966 of the binding of [3H]CPP to the NMDA receptor complex.[Pubmed: 2147657]

The enantiomers of the strychnine-insensitive glycine antagonist, HA-966 (1-hydroxy-3-amino-pyrrolidone-2), stereoselectively enhance binding of the N-methyl-D-aspartate (NMDA) competitive antagonist, [3H]CPP (3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid) to rat brain synaptosomal membranes. The enhancement by the more potent (R)-HA-966 is competitively inhibited by the glycine antagonist 7-chlorokynurenic acid and noncompetitively by the polyamine spermine. Thus, (R)-HA-966, apparently at the glycine site, enhances the binding of antagonist to the NMDA receptor, possibly through a mechanism partially in common with that of spermine.


(R)-CPP,126453-07-4,Membrane Transporter/Ion Channel,NMDA Receptor, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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