(R)-Baclofen hydrochlorideGABAB receptor agonist CAS# 63701-55-3 |
- Anguizole
Catalog No.:BCC1365
CAS No.:442666-98-0
- Asunaprevir (BMS-650032)
Catalog No.:BCC1374
CAS No.:630420-16-5
- Balapiravir
Catalog No.:BCC1396
CAS No.:690270-29-2
Quality Control & MSDS
Number of papers citing our products
Chemical structure
3D structure
| Cas No. | 63701-55-3 | SDF | Download SDF |
| PubChem ID | 44601 | Appearance | Powder |
| Formula | C10H13Cl2NO2 | M.Wt | 250.12 |
| Type of Compound | N/A | Storage | Desiccate at -20°C |
| Solubility | Soluble in DMSO | ||
| Chemical Name | (3R)-4-amino-3-(4-chlorophenyl)butanoic acid;hydrochloride | ||
| SMILES | C1=CC(=CC=C1C(CC(=O)O)CN)Cl.Cl | ||
| Standard InChIKey | WMNUVYYLMCMHLU-QRPNPIFTSA-N | ||
| Standard InChI | InChI=1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1 | ||
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. We recommend that you prepare and use the solution on the same day. However, if the test schedule requires, the stock solutions can be prepared in advance, and the stock solution must be sealed and stored below -20℃. In general, the stock solution can be kept for several months. Before use, we recommend that you leave the vial at room temperature for at least an hour before opening it. |
||
| About Packaging | 1. The packaging of the product may be reversed during transportation, cause the high purity compounds to adhere to the neck or cap of the vial.Take the vail out of its packaging and shake gently until the compounds fall to the bottom of the vial. 2. For liquid products, please centrifuge at 500xg to gather the liquid to the bottom of the vial. 3. Try to avoid loss or contamination during the experiment. |
||
| Shipping Condition | Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other couriers with RT, or blue ice upon request. | ||
(R)-Baclofen hydrochloride Dilution Calculator
(R)-Baclofen hydrochloride Molarity Calculator
| 1 mg | 5 mg | 10 mg | 20 mg | 25 mg | |
| 1 mM | 3.9981 mL | 19.9904 mL | 39.9808 mL | 79.9616 mL | 99.952 mL |
| 5 mM | 0.7996 mL | 3.9981 mL | 7.9962 mL | 15.9923 mL | 19.9904 mL |
| 10 mM | 0.3998 mL | 1.999 mL | 3.9981 mL | 7.9962 mL | 9.9952 mL |
| 50 mM | 0.08 mL | 0.3998 mL | 0.7996 mL | 1.5992 mL | 1.999 mL |
| 100 mM | 0.04 mL | 0.1999 mL | 0.3998 mL | 0.7996 mL | 0.9995 mL |
| * Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations. | |||||
Calcutta University
University of Minnesota
University of Maryland School of Medicine
University of Illinois at Chicago
The Ohio State University
University of Zurich
Harvard University
Colorado State University
Auburn University
Yale University
Worcester Polytechnic Institute
Washington State University
Stanford University
University of Leipzig
Universidade da Beira Interior
The Institute of Cancer Research
Heidelberg University
University of Amsterdam
University of Auckland
TsingHua University
The University of Michigan
Miami University
DRURY University
Jilin University
Fudan University
Wuhan University
Sun Yat-sen University
Universite de Paris
Deemed University
Auckland University
The University of Tokyo
Korea University
(R)-Baclofen hydrochloride is a derivative of gamma-aminobutyric acid (GABA) primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism.
- 2-(Dimethylamino)ethanesulfonic acid
Catalog No.:BCN1752
CAS No.:637-95-6
- Pramoxine HCl
Catalog No.:BCC4705
CAS No.:637-58-1
- Clofibrate
Catalog No.:BCC5308
CAS No.:637-07-0
- Boc-D-Ser-OH
Catalog No.:BCC3447
CAS No.:6368-20-3
- Nisoldipine
Catalog No.:BCC4809
CAS No.:63675-72-9
- H-D-Asp-Obzl
Catalog No.:BCC2895
CAS No.:6367-42-6
- H-Lys(Z)-OBzl.HCl
Catalog No.:BCC2987
CAS No.:6366-70-7
- Betaxolol HCl
Catalog No.:BCC4343
CAS No.:63659-19-8
- Z-D-Glu-OH
Catalog No.:BCC2775
CAS No.:63648-73-7
- Gamma-Methoxyisoeugenol
Catalog No.:BCN3999
CAS No.:63644-71-3
- 1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-diene
Catalog No.:BCN1388
CAS No.:63644-68-8
- Coniferyl ferulate
Catalog No.:BCN8543
CAS No.:63644-62-2
- Z-Phenylalaninol
Catalog No.:BCC2716
CAS No.:6372-14-1
- Paspalinine
Catalog No.:BCN7386
CAS No.:63722-91-8
- Pseudoprotogracillin
Catalog No.:BCC8354
CAS No.:637349-03-2
- AEG 3482
Catalog No.:BCC8088
CAS No.:63735-71-7
- 3'-Amino-4'-methoxyacetanilide
Catalog No.:BCC8611
CAS No.:6375-47-9
- 6-Chloromelatonin
Catalog No.:BCC6651
CAS No.:63762-74-3
- 12alpha-Hydroxygrandiflorenic acid
Catalog No.:BCN4823
CAS No.:63768-17-2
- Cyclosporin D
Catalog No.:BCC6444
CAS No.:63775-96-2
- trans-Methylisoeugenol
Catalog No.:BCN6558
CAS No.:6379-72-2
- Desonide
Catalog No.:BCC4967
CAS No.:638-94-8
- alpha-Amyrin
Catalog No.:BCN3341
CAS No.:638-95-9
- beta-Amyrone
Catalog No.:BCN4179
CAS No.:638-97-1
Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats.[Pubmed:8773775]
Brain Res. 1996 Apr 29;718(1-2):129-37.
This study examined the sites in the central nervous system at which subcutaneously-administered R(+)-baclofen hydrochloride (baclofen), the most active isomer of this prototypic gamma-aminobutyric acid (GABA)B receptor agonist, acts to produce antinociception in the rat. To determine whether baclofen acts in the spinal cord, either saline or the GABAB receptor antagonist CGP 35348 was injected intrathecally in rats pretreated 24 min earlier with 1 or 3 mg/kg s.c. baclofen. Intrathecal (i.t.) injection of 3 or 10 micrograms of CGP 35348 antagonized the increase in tail-flick and hot-plate latency produced by either dose of baclofen. To determine whether baclofen acts at sites in the ventromedial medulla (VMM), either saline or CGP 35348 was microinjected in the nucleus raphe magnus or nucleus reticularis gigantocellularis pars alpha of rats pretreated 24 min earlier with 1 or 3 mg/kg s.c. baclofen. Microinjection of 0.5 or 3 micrograms of CGP 35348 at sites in the VMM produced at best only a very modest attenuation of the antinociceptive effects of baclofen. These data suggest that systemically-administered baclofen acts at sites in both the spinal cord and the VMM, but that its antinociceptive effects are likely to be mediated to a greater extent by a spinal, rather than medullary site of action. However, a definitive comparison of the relative contribution of GABAB receptors in these two regions is precluded by differences in the diffusion and concentrations of the antagonist in the spinal cord and brainstem. Finally, microinjection of 0.5 or 3.0 micrograms of CGP 35348 in the nucleus raphe magnus or nucleus reticularis gigantocellularis pars alpha of saline-pretreated rats did not alter tail-flick or hot-plate latency. This finding suggests that, unlike GABAA receptors, GABAB receptors do not mediate the tonic GABAergic input to neurons in these nuclei.
