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(R)-Baclofen hydrochlorideGABAB receptor agonist

(R)-Baclofen hydrochloride

Catalog No. BCC4123
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Quality Control of (R)-Baclofen hydrochloride

Chemical structure

(R)-Baclofen hydrochloride

(R)-Baclofen hydrochloride Dilution Calculator

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Chemical Properties of (R)-Baclofen hydrochloride

Cas No. 63701-55-3 SDF Download SDF
Chemical Name (3R)-4-amino-3-(4-chlorophenyl)butanoic acid;hydrochloride
Standard InChI InChI=1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1
Formula C10H13Cl2NO2 M.Wt 250.12
Solubility Soluble in DMSO
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (R)-Baclofen hydrochloride

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.9981 mL 19.9904 mL 39.9808 mL 79.9616 mL 99.952 mL
5 mM 0.7996 mL 3.9981 mL 7.9962 mL 15.9923 mL 19.9904 mL
10 mM 0.3998 mL 1.999 mL 3.9981 mL 7.9962 mL 9.9952 mL
50 mM 0.08 mL 0.3998 mL 0.7996 mL 1.5992 mL 1.999 mL
100 mM 0.04 mL 0.1999 mL 0.3998 mL 0.7996 mL 0.9995 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Background on (R)-Baclofen hydrochloride

(R)-Baclofen hydrochloride is a derivative of gamma-aminobutyric acid (GABA) primarily used to treat spasticity and is in the early research stages for use for the treatment of alcoholism.

References on (R)-Baclofen hydrochloride

Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats.[Pubmed: 8773775]

This study examined the sites in the central nervous system at which subcutaneously-administered R(+)-baclofen hydrochloride (baclofen), the most active isomer of this prototypic gamma-aminobutyric acid (GABA)B receptor agonist, acts to produce antinociception in the rat. To determine whether baclofen acts in the spinal cord, either saline or the GABAB receptor antagonist CGP 35348 was injected intrathecally in rats pretreated 24 min earlier with 1 or 3 mg/kg s.c. baclofen. Intrathecal (i.t.) injection of 3 or 10 micrograms of CGP 35348 antagonized the increase in tail-flick and hot-plate latency produced by either dose of baclofen. To determine whether baclofen acts at sites in the ventromedial medulla (VMM), either saline or CGP 35348 was microinjected in the nucleus raphe magnus or nucleus reticularis gigantocellularis pars alpha of rats pretreated 24 min earlier with 1 or 3 mg/kg s.c. baclofen. Microinjection of 0.5 or 3 micrograms of CGP 35348 at sites in the VMM produced at best only a very modest attenuation of the antinociceptive effects of baclofen. These data suggest that systemically-administered baclofen acts at sites in both the spinal cord and the VMM, but that its antinociceptive effects are likely to be mediated to a greater extent by a spinal, rather than medullary site of action. However, a definitive comparison of the relative contribution of GABAB receptors in these two regions is precluded by differences in the diffusion and concentrations of the antagonist in the spinal cord and brainstem. Finally, microinjection of 0.5 or 3.0 micrograms of CGP 35348 in the nucleus raphe magnus or nucleus reticularis gigantocellularis pars alpha of saline-pretreated rats did not alter tail-flick or hot-plate latency. This finding suggests that, unlike GABAA receptors, GABAB receptors do not mediate the tonic GABAergic input to neurons in these nuclei.


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