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[D-Phe12,Leu14]-Bombesin

[D-Phe12,Leu14]-Bombesin

Catalog No. BCC6020
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1mg $116.00 Ship Within 7 Days
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Quality Control of [D-Phe12,Leu14]-Bombesin

Chemical structure

[D-Phe12,Leu14]-Bombesin

Biological Activity of [D-Phe12,Leu14]-Bombesin

Bombesin receptor antagonist that inhibits bombesin binding to rat brain with an IC50 value of 2 μM. Inhibits amylase release in vitro (IC50 = 4 μM) and attenuates bombesin-mediated suppression of food intake in vivo.

[D-Phe12,Leu14]-Bombesin Dilution Calculator

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[D-Phe12,Leu14]-Bombesin Molarity Calculator

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Chemical Properties of [D-Phe12,Leu14]-Bombesin

Cas No. 108437-88-3 SDF Download SDF
Sequence XQRLGNQWAVGFLL

(Modifications: X = Glp, Phe-12 = D-Phe, Leu-14 = C-terminal amide)

SMILES CC(C)CC(C(=O)N)NC(=O)C(CC(C)C)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)C(C(C)C)NC(=O)C(C)NC(=O)C(CC2=CNC3=CC=CC=C32)NC(=O)C(CCC(=O)N)NC(=O)C(CC(=O)N)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCC(=O)N)NC(=O)C4CCC(=O)N4
Standard InChIKey PWGHKRYOBBMXGB-TVXZQRGPSA-N
Standard InChI InChI=1S/C75H114N22O18/c1-37(2)28-50(63(79)104)93-71(112)52(30-39(5)6)95-72(113)53(31-42-16-11-10-12-17-42)88-61(103)36-85-74(115)62(40(7)8)97-64(105)41(9)86-70(111)54(32-43-34-83-45-19-14-13-18-44(43)45)96-69(110)49(22-25-57(77)99)92-73(114)55(33-58(78)100)89-60(102)35-84-65(106)51(29-38(3)4)94-66(107)46(20-15-27-82-75(80)81)90-68(109)48(21-24-56(76)98)91-67(108)47-23-26-59(101)87-47/h10-14,16-19,34,37-41,46-55,62,83H,15,20-33,35-36H2,1-9H3,(H2,76,98)(H2,77,99)(H2,78,100)(H2,79,104)(H,84,106)(H,85,115)(H,86,111)(H,87,101)(H,88,103)(H,89,102)(H,90,109)(H,91,108)(H,92,114)(H,93,112)(H,94,107)(H,95,113)(H,96,110)(H,97,105)(H4,80,81,82)/t41-,46-,47-,48-,49-,50-,51-,52-,53+,54-,55-,62-/m0/s1
Formula C75H114N22O18 M.Wt 1610.9
Solubility Soluble to 10 mg/ml in water
Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of [D-Phe12,Leu14]-Bombesin

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 0.6208 mL 3.1039 mL 6.2077 mL 12.4154 mL 15.5193 mL
5 mM 0.1242 mL 0.6208 mL 1.2415 mL 2.4831 mL 3.1039 mL
10 mM 0.0621 mL 0.3104 mL 0.6208 mL 1.2415 mL 1.5519 mL
50 mM 0.0124 mL 0.0621 mL 0.1242 mL 0.2483 mL 0.3104 mL
100 mM 0.0062 mL 0.031 mL 0.0621 mL 0.1242 mL 0.1552 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

References on [D-Phe12,Leu14]-Bombesin

Conformation studies on bombesin receptor antagonists: 500 MHz NMR and CD characterization of synthetic (D-Phe12, Leu14)-bombesin.[Pubmed: 2545203]


The conformation flexibility of the tetradecapeptide hormone bombesin and its synthetic antagonist (DPhe12, Leu14)-bombesin has been studied using nuclear magnetic resonance and circular dichroism techniques. The spectral features observed indicate that the ordered structure present in the C-terminal pentapeptide moiety of native BBS is lost in the (DPhe12, Leu14) analog.

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[D-Phe12,Leu14]-Bombesin,108437-88-3,GPCR/G protein,Bombesin Receptors, supplier, inhibitor,Antagonist,Blocker,Modulator,Agonist, activators, activates, potent, BioCrick

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