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(20R)-Protopanaxdiol

(20R)-Protopanaxdiol

Catalog No. BCN1078
Size Price Stock
20mg $138 In stock
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Quality Control of (20R)-Protopanaxdiol

Chemical structure

(20R)-Protopanaxdiol

Biological Activity of (20R)-Protopanaxdiol

1. Protopanaxdiol has the effect of anti-tumor through increasing the activity of body immunity, inhibiting tumor interstitial microvascular density and its proliferation activity, improving the lymphocyte transformation, the activity of NK cells and the contents of IL-2 significantly.
2. Protopanaxdiol prevents and heals obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet.

(20R)-Protopanaxdiol Dilution Calculator

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Chemical Properties of (20R)-Protopanaxdiol

Cas No. 7755-01-3 SDF Download SDF
Chemical Name (3S,8R,9R,10R,12R,13R,14S,17S)-17-[(2R)-2-hydroxy-6-methylhept-5-en-2-yl]-4,4,8,10,14-pentamethyl-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol
SMILES CC(C)=CCC[C@@](C)(O)[C@H]1CC[C@@]2(C)[C@@H]1[C@H](O)C[C@@H]3[C@@]4(C)CC[C@H](O)C(C)(C)C4CC[C@@]23C
Standard InChIKey PYXFVCFISTUSOO-OIORDRSNSA-N
Standard InChI InChI=1S/C30H52O3/c1-19(2)10-9-14-30(8,33)20-11-16-29(7)25(20)21(31)18-23-27(5)15-13-24(32)26(3,4)22(27)12-17-28(23,29)6/h10,20-25,31-33H,9,11-18H2,1-8H3/t20-,21+,22?,23+,24-,25-,27-,28+,29-,30+/m0/s1
Type of Compound Triterpenoids Appearance White powder
Formula C30H52O3 M.Wt 460.74
Solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Packaging according to customer requirements(5mg, 10mg, 20mg and more). Ship via FedEx, DHL, UPS, EMS or other courier with RT , or blue ice upon request.

Preparing Stock Solutions of (20R)-Protopanaxdiol

1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.1704 mL 10.8521 mL 21.7042 mL 43.4084 mL 54.2605 mL
5 mM 0.4341 mL 2.1704 mL 4.3408 mL 8.6817 mL 10.8521 mL
10 mM 0.217 mL 1.0852 mL 2.1704 mL 4.3408 mL 5.4261 mL
50 mM 0.0434 mL 0.217 mL 0.4341 mL 0.8682 mL 1.0852 mL
100 mM 0.0217 mL 0.1085 mL 0.217 mL 0.4341 mL 0.5426 mL
* Note: If you are in the process of experiment, it's necessary to make the dilution ratios of the samples. The dilution data above is only for reference. Normally, it's can get a better solubility within lower of Concentrations.

Preparation of (20R)-Protopanaxdiol

This product is isolated and purified from the roots of Panax ginseng C. A. Mey.

References on (20R)-Protopanaxdiol

Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet.[Pubmed: 20627120]


Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1mg/ml. It inhibited hydrolysis of about 83.2% of triolein at about 1mg/ml of PDG. However, PTG showed no inhibitory activity. Therefore, anti-obesity activity of PDG was evaluated in mice fed a high-fat diet. The results demonstrated that PDG was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet.

Molecular mechanism of protopanaxadiol saponin fraction-mediated anti-inflammatory actions.[Pubmed: 25535478]


These results strongly suggest that the anti-inflammatory action of PPD-SF could be mediated by a reduction in the activation of p38-, JNK2-, and TANK-binding-kinase-1-linked pathways and their corresponding transcription factors (ATF2 and IRF3).

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